Calea Zacatechichi gets this grand title from its ability to help the user enter a state of lucid dreaming, where they become aware of their own self during the dream. The Chontal peoples of Mexico believe this makes it easier to receive prophetic and divinatory messages, which makes the plant seem connected to God. Some shamans would smoke the plant but as this can cause nausea, generally it is taken as a tea.
On a less spiritual level, Calea Zacatechichi is also used for general relaxation and to aid sleep, but also to increase the metabolism, boost appetite and aid digestion. The noticeable effects tend to be a dream-like state, although some people find it actually clears their minds rather than clouds them. Some users report longer-term mental enhancement.
With regards to dreams, anyone who has difficulty remembering their dreams should find that Calea Zacatechichi helps with this. Dreams are more vivid, easier to remember, and lucid dreaming becomes possible. A very few users who take the plant when wide awake report visual effects, even though there is no proof that this plant has any hallucinogenic properties.
Expect a bitter taste when you drink made tea with Calea zacatechichi. As with all substances, start with a small dose and work your way up to find what works best for you.